%0 Journal Article
%T Magnetic compression anastomosis gastrojejunostomy: feasibility and efficacy of a novel device in a swine model.
%A Gagner M
%A Krinke T
%A Lapointe-Gagner M
%A Buchwald JN
%J Surg Obes Relat Dis
%V 0
%N 0
%D 2024 May 20
%M 38879418
%F 3.709
%R 10.1016/j.soard.2024.04.451
%X <B>BACKGROUND: </B>Means of addressing technical challenges in forming gastrojejunostomy (GJ) anastomoses and maintaining their patency are sought.<BR><B>OBJECTIVE: </B>Evaluation of preclinical feasibility and healing efficacy of a novel linear magnetic compression anastomosis (MCA) device to form a patent GJ versus sutured jejunal enterotomy (JE) sites in swine.<BR><B>METHODS: </B>Single-center veterinary testing facility.<BR><B>METHODS: </B>Feasibility of 3 prototype sizes (4, 6, and 8 cm) of a metal MCA device (MCAD) to form a patent GJ was evaluated over 6 weeks. A distal magnet was laparoscopically inserted in the jejunum, a proximal magnet was placed gastroscopically in the stomach; magnets were aligned to gradually form an anastomosis, self-detached, and be expelled. At necropsy, MCAs were assessed for patency and compared with JE tissues to evaluate wound healing.<BR><B>RESULTS: </B>MCADs aligned at the GJ location without complications. In 5/6 MCAD pairs, dislodgement occurred between 7 and 26 days; expulsion 13-31 days; 1 MCAD pair was retained in the stomach. At necropsy, all pigs were healthy, gaining a mean 15.0 kg. Anastomoses were not adequately patent in 2/4 pigs receiving the 4-cm or 6-cm MCADs because their linear length was too small. But, anastomoses of both pigs receiving the 8-cm MCADs maintained full patency. Minimal inflammation and fibrosis were seen in MCA specimens versus sutured enterotomies.<BR><B>CONCLUSIONS: </B>A novel linear MCA device was feasible and effectively created a patent GJ anastomosis in swine with minimal inflammation and fibrosis. The MCAD may be appropriate for clinical evaluation.