%0 Journal Article %T The Foundational Science of Endogenous Opioids and Their Receptors. %A Tache S %A Kerr PL %A Sirbu C %J Adv Neurobiol %V 35 %N 0 %D 2024 %M 38874716 暂无%R 10.1007/978-3-031-45493-6_2 %X The function of endogenous opioids spans from initiating behaviors that are critical for survival, to responding to rapidly changing environmental conditions. A network of interconnected systems throughout the body characterizes the endogenous opioid system (EOS). EOS receptors for beta-endorphin, enkephalin, dynorphin, and endomorphin underpin the diverse functions of the EOS across biological systems. This chapter presents a succinct yet comprehensive summary of the structure of the EOS, EOS receptors, and their relationship to other biological systems.