%0 Journal Article
%T Diagnostic potential of endothelin-1 in peri-implant diseases: a cross-sectional study.
%A Saito Y
%A Nodai T
%A Munemasa T
%A Mukaibo T
%A Kondo Y
%A Masaki C
%A Hosokawa R
%J Int J Implant Dent
%V 10
%N 1
%D 2024 Jun 14
%M 38874661
%F 2.984
%R 10.1186/s40729-024-00551-0
%X <B>OBJECTIVE: </B>This study aimed to evaluate the potential of Endothelin-1 (ET-1), a peptide derived from vascular endothelial cells, as a biomarker for diagnosing peri-implant diseases.<BR><B>METHODS: </B>A cohort of 29 patients with a total of 76 implants was included in this study and subsequently divided into three groups based on peri-implant clinical parameters and radiographic examination: healthy (peri-implant health) (n = 29), mucositis (n = 22), and peri-implantitis (n = 25) groups. The levels of ET-1 (ρg/site) and interleukin (IL)-1β (ρg/site) in peri-implant sulcus fluid (PISF) samples were determined using enzyme immunoassay. Statistical analyses were conducted using Kruskal-Wallis and Steel-Dwass tests. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to evaluate the diagnostic performance of the biomarkers.<BR><B>RESULTS: </B>ET-1 levels were significantly elevated in the peri-implantitis group compared to those in the healthy group, and were highest in the peri-implant mucositis group. Additionally, IL-1β levels were significantly higher in the peri-implantitis group than those in the healthy group. ROC curve analysis indicated that ET-1 exhibited superior area under the curve values, sensitivity, and specificity compared to those of IL-1β.<BR><B>CONCLUSIONS: </B>Our findings suggest that the presence of ET-1 in PISF plays a role in peri-implant diseases. Its significantly increased expression in peri-implant mucositis indicates its potential for enabling earlier and more accurate assessments of peri-implant inflammation when combined with conventional examination methods.