%0 Journal Article
%T Investigation of the Status of Immune Checkpoint Molecules in Meningiomas by Immunohistochemistry.
%A Saygin I
%A Cakir E
%A Kazaz SN
%A Guvercin AR
%A Eyuboglu I
%A Ustaoglu MM
%J Turk Neurosurg
%V 34
%N 4
%D 2024 Aug 1
%M 38874241
%F 0.972
%R 10.5137/1019-5149.JTN.43334-23.2
%X OBJECTIVE: To investigate the status of immune checkpoint molecules (CTLA-4 and TIM-3) in meningiomas and thus contribute to the development of new personalized treatment strategies.
METHODS: We utilized 402 cases of meningioma for this study. New blocks were prepared using the tissue microarray method, and sections obtained from these blocks were immunohistochemically stained with CTLA-4 and TIM-3 antibodies. Subsequently, statistical analysis were performed.
RESULTS: Our findings revealed that CTLA-4 expression were observed in 25.1% of meningiomas. CTLA-4 expression and the number of expressing lymphocytes were found to be significantly higher in high-grade tumors and in those with brain invasion. Meningiomas with staining of immune cells with TIM-3 are 3.5%, and the tumor grade was correlated with the number of immune cells expressing TIM-3.
CONCLUSIONS: Immune checkpoint molecules (CTLA-4 and TIM-3) with varying levels of expression can serve as prognostic and predictive biomarkers, as well as important targets for therapy. Drugs developed for CTLA-4 and TIM-3 molecules may prove to be more effective in treating meningiomas with high-grade, brain-invading, spontaneous necrosis, and macronucleolus.