%0 Journal Article
%T Predictive model to differentiate chronic histaminergic angioedema and chronic spontaneous urticaria with angioedema.
%A Láinez-Nuez A
%A Salas-Parra G
%A Juárez-Guerrero A
%A Picó-Peris A
%A Baeza ML
%J J Allergy Clin Immunol Glob
%V 3
%N 3
%D 2024 Aug
%M 38873244
暂无%R 10.1016/j.jacig.2024.100278
%X <B>UNASSIGNED: </B>Chronic histaminergic angioedema (CHA) may be classified as a separate acquired angioedema (AE) or as an endotype of chronic spontaneous urticaria (CSU). A recent study suggested them to be independent pathologies.<BR><B>UNASSIGNED: </B>We carried out an exhaustive analysis between CHA and AE-CSU to explore the possible differentiation between them on the bases of a series of predictors.<BR><B>UNASSIGNED: </B>An observational, retrospective, cross-sectional, and exploratory study was designed. Fifty-six CHA and 40 AE-CSU patients were included. Data were extracted from the year before and year after time of diagnosis. A predictive model was generated by logistic regression, and its discriminatory power was assessed using the area under the receiver operating characteristic curve.<BR><B>UNASSIGNED: </B>The average frequency of AE attacks per year turned out to be higher in the AE-CSU group than in the CHA group, both before (median [interquartile range] 12 [43] vs 8 [16]) and after (24.3 [51.2] vs 2 [4.25]) diagnosis, respectively. The uvula was more frequently affected in CHA. No other differences were found. However, using 7 clinical characteristics of the patients, a multiple logistic regression model was able to predict, with a specificity of 86.4%, a sensitivity of 92.3%, and an area under the curve of 95.1% (P = .024), that CHA and AE-CSU behaved differently.<BR><B>UNASSIGNED: </B>CHA has similar characteristics to AE-CSU, although they slightly differed in the frequency of attacks and their location. Despite its similarities, a multiple logistic regression model that used clinical and evolutionary characteristics allowed the differentiation of both pathologies and supports the idea that these 2 entities are independent.