%0 Journal Article
%T Dorsal raphe nucleus to basolateral amygdala 5-HTergic neural circuit modulates restoration of consciousness during sevoflurane anesthesia.
%A Yu Q
%A Wang Y
%A Gu L
%A Shao W
%A Gu J
%A Liu L
%A Lian X
%A Xu Q
%A Zhang Y
%A Yang Y
%A Zhang Z
%A Wu Y
%A Ma H
%A Shen Y
%A Ye W
%A Wu Y
%A Yang H
%A Chen L
%A Nagayasu K
%A Zhang H
%J Biomed Pharmacother
%V 176
%N 0
%D 2024 Jul 11
%M 38870632
%F 7.419
%R 10.1016/j.biopha.2024.116937
%X The advent of general anesthesia (GA) has significant implications for clinical practice. However, the exact mechanisms underlying GA-induced transitions in consciousness remain elusive. Given some similarities between GA and sleep, the sleep-arousal neural nuclei and circuits involved in sleep-arousal, including the 5-HTergic system, could be implicated in GA. Herein, we utilized pharmacology, optogenetics, chemogenetics, fiber photometry, and retrograde tracing to demonstrate that both endogenous and exogenous activation of the 5-HTergic neural circuit between the dorsal raphe nucleus (DR) and basolateral amygdala (BLA) promotes arousal and facilitates recovery of consciousness from sevoflurane anesthesia. Notably, the 5-HT1A receptor within this pathway holds a pivotal role. Our findings will be conducive to substantially expanding our comprehension of the neural circuit mechanisms underlying sevoflurane anesthesia and provide a potential target for modulating consciousness, ultimately leading to a reduction in anesthetic dose requirements and side effects.