%0 Journal Article
%T Preoperative Low Creatine Kinase as a Poor Prognostic Factor in Patients with Colorectal Cancer.
%A Ushigome M
%A Shimada H
%A Kaneko T
%A Miura Y
%A Yoshida K
%A Suzuki T
%A Kagami S
%A Kurihara A
%A Funahashi K
%J J Gastrointest Cancer
%V 55
%N 3
%D 2024 Sep 13
%M 38869820
暂无%R 10.1007/s12029-024-01069-9
%X <B>OBJECTIVE: </B>This study aimed to evaluate the clinicopathological and prognostic significance of preoperative serum creatine kinase (CK) levels in colorectal cancer.<BR><B>METHODS: </B>This study analyzed 1169 patients with colorectal cancer at stages 0 (n = 35), I (n = 301), II (n = 456), III (n = 339), and IV (n = 38). The CK cut-off value was 52 U/L to predict recurrence based on receiver operative characteristics curve. Clinicopathological factors were compared between the low (< 52 U/L) and high CK groups (≥ 52 U/L). The multivariate analysis evaluated relapse-free survival (RFS) and overall survival (OS) following CK status.<BR><B>RESULTS: </B>The female sex, elderly age (≥ 75), deep tumor (pT4), and carcinoembryonic antigen (+) were independently associated with low CK status. The recurrent rate was significantly higher in the low CK group than in the high CK group (19.1% vs. 11.7%, p < 0.001). Elderly age, pT4, pN (+), preoperative carbohydrate antigen (CA) 19-9 (+), and low CK status were independent risk factors for RFS. Elderly age, pT4, pN (+), preoperative CA19-9 (+), and low CK status were independent risk factors for OS.<BR><B>CONCLUSIONS: </B>Preoperative low CK status was associated with deep tumors and was a poor prognostic factor in patients with colorectal cancer.