%0 Journal Article
%T Ficini Reaction with Acrylates for the Stereoselective Synthesis of Aminocyclobutanes.
%A Robert EGL
%A Waser J
%J Chemistry
%V 0
%N 0
%D 2024 Jun 13
%M 38869382
%F 5.02
%R 10.1002/chem.202401810
%X The first Ficini reaction between ynamides and acrylates is reported herein. The reaction is catalyzed by B(C6F5)3 acting as a Lewis acid and is giving access to stable tri-substituted aminocyclobutenes in high yield. The resulting products can be hydrogenated and epimerized under basic conditions or in presence of a Lewis acid, providing two distinct trans- aminocyclobutane monoester stereoisomers in high yield and diastereoisomeric ratio (up to quantitative yield and >99:1 dr).