%0 Case Reports
%T Pseudo Elevation of TSH and ACTH Caused by Heterophilic Antibodies: a Case Report and Literature Review.
%A Sun HG
%A Xu XP
%A He LQ
%J Clin Lab
%V 70
%N 6
%D 2024 Jun 1
%M 38868895
%F 1.053
%R 10.7754/Clin.Lab.2024.240122
%X <B>BACKGROUND: </B>TSH and ACTH are crucial hormones for diagnosing thyroid and adrenal diseases, and incorrect test reports can cause significant harm to patients.<BR><B>METHODS: </B>The TSH and ACTH levels on the testing system of our laboratory were measured using "sandwich" assays. The patient had heterophilic antibodies in their body, causing a false increase in TSH and ACTH levels.<BR><B>RESULTS: </B>TSH on the Abbott platform was 59.7 μIU/mL and on the Roche platform it was 4.33 μIU/mL. After pretreatment with HBR it was 3.95 μIU/mL; ACTH on the SIEMENS platform was 263.5 pg/mL, on the Abbott platform it was 47.6 pg/mL. After pretreatment with HBR it was 36.5 pg/mL.<BR><B>CONCLUSIONS: </B>The patient's serum contains heterophilic antibodies, which interfere with the TSH and ACTH tested by this method.