%0 Journal Article
%T Beyond the danger signal: RNA aggregates orchestrate immunotherapy.
%A Shubhra QTH
%A Feczkó T
%A Cai Q
%J Trends Mol Med
%V 30
%N 8
%D 2024 Aug 11
%M 38866645
%F 15.272
%R 10.1016/j.molmed.2024.05.018
%X Mendez-Gomez et al. recently demonstrated the transformative potential of RNA-lipid particle aggregates (RNA-LPAs) in immunotherapy. By reprogramming the tumor microenvironment (TME) and potentiating antitumor immunity, RNA-LPAs target primary tumors and elicit robust systemic immunity. This innovative platform holds promise for translating preclinical success into tangible clinical benefits.