%0 Journal Article
%T A review on RNA interference studies in Anophelines to reveal candidate genes for malaria transmission blocking vaccine.
%A Yadav M
%A Dahiya N
%A Janjoter S
%A Kataria D
%A Dixit R
%A Sehrawat N
%J Life Sci
%V 351
%N 0
%D 2024 Aug 15
%M 38866221
%F 6.78
%R 10.1016/j.lfs.2024.122822
%X Malaria is a major public health concern. The development of parasite-based vaccine RTS/AS01 has some therapeutic value but its lower efficacy is one of the major limitations. Mosquito-based transmission-blocking vaccines could have a higher potential for parasite inhibition within the mosquitoes. Several genes of mosquito midgut, salivary gland, hemolymph, etc. get activate in response to the Plasmodium-infected blood and helps in parasite invasion directly or indirectly inside the mosquito. The studies of such genes provided a new insight into developing the more efficient vaccines. In the field of malaria genetics research, RNAi has become an innovative strategy used to identify mosquito candidate genes for transmission-blocking vaccines. This review targeted the gene studies that have been conducted in the period 2000-2023 in different malaria vectors against different malarial parasites using the RNAi approach to reveal mosquito novel gene candidates for vaccine development.