%0 Journal Article
%T Biological Properties of Mentha viridis L. Essential Oil and Its Main Monoterpene Constituents.
%A Omari NE
%A Chamkhi I
%A Bakrim S
%A Aanniz T
%A Benali T
%A Akhazzane M
%A Ullah R
%A Alotaibi A
%A Bari A
%A Elhrech H
%A Zengin G
%A Bouyahya A
%J Chem Biodivers
%V 0
%N 0
%D 2024 Jun 12
%M 38865194
%F 2.745
%R 10.1002/cbdv.202401209
%X This research aimed to evaluate the antidiabetic, dermatoprotective, and antibacterial activities of Mentha viridis L. essential oil (MVEO) collected in the province of Ouezzane (Northwest Morocco). Gas chromatography-mass spectrometry (GC-MS) analysis revealed that the main constituents of MVEO were carvone (37.26 %), 1,8-cineole (11.82 %), limonene (5.27 %), α-terpineol (4.16 %), and β-caryophyllene (4.04 %). MVEO showed strong inhibitory effects on α-amylase and α-glucosidase activities, exceeding those of acarbose, but weak anti-elastase activity. The main compounds, β-caryophyllene (IC50=79.91±2.24 and 62.08±2.78 μg/mL) and limonene (IC50=90.73±3.47 and 68.98±1, 60 μg/mL), demonstrated the strongest inhibitory effects on both digestive enzymes (α-glucosidase and α-amylase, respectively). In silico investigations, using molecular docking, also showed the inhibitory potential of these bioactive compounds against the enzymes tested. In conclusion, MVEO, due to its main components such as limonene, 1,8-cineole, β-caryophyllene, carvone, and α-terpineol, shows promising prospects for drug discovery and natural therapeutic applications.