%0 Journal Article
%T Outcomes of non-angiosarcoma radiation-associated soft tissue sarcomas of the chest.
%A Garayua-Cruz L
%A Broida SE
%A Okuno SH
%A Robinson SI
%A Siontis BL
%A Welliver MX
%A Wilke BK
%A Goulding KA
%A Rose PS
%A Houdek MT
%J J Surg Oncol
%V 130
%N 1
%D 2024 Jul 12
%M 38864186
%F 2.885
%R 10.1002/jso.27686
%X <B>BACKGROUND: </B>Radiation-associated soft tissue sarcomas (RA-STS) are rare complications of patients receiving radiation therapy (RT) and are generally associated with a poor prognosis. Most of the literature surrounding RA-STS of the chest is centered on angiosarcoma. Therefore, we aim to document the management and outcome of patients with non-angiosarcoma RA-STS of the chest.<BR><B>METHODS: </B>We reviewed 17 patients (all female, median age 65 years) diagnosed with RA-STS. The most common primary malignancy was breast carcinoma (n = 15), with a median RT dose of 57.9 Gy. All patients underwent surgical resection; five patients (29%) received radiotherapy; and five patients (29%) received peri-operative chemotherapy.<BR><B>RESULTS: </B>The 5-year local recurrence and metastatic-free survival were 61% and 60%, while the 5-year disease-specific survival was 53%. Local recurrence was associated with death due to disease (HR 9.06, p = 0.01). Complications occurred in nine of patients, most commonly due to a wound complication (n = 7). At the most recent follow-up, the median Musculoskeletal Tumor Society Score was 63%.<BR><B>CONCLUSIONS: </B>RA-STS involving the chest wall are aggressive tumors with a high risk of local relapse and death due to disease. Local recurrence was associated with death due to disease; as such, we recommend aggressive surgical management with evaluation for adjuvant therapies.