%0 Journal Article
%T Optimizing ATR Inhibition and Cisplatin Synergy in Ewing Sarcoma.
%A Ohmura S
%A Grünewald TGP
%J Clin Cancer Res
%V 30
%N 16
%D 2024 Aug 15
%M 38861280
%F 13.801
%R 10.1158/1078-0432.CCR-24-1047
%X EWSR1::FLI1-mediated dysregulation of cellular machinery opens up potential new avenues for Ewing sarcoma treatment. A recent study demonstrates that pharmacologic ATR kinase inhibition dramatically synergizes with low-dose cisplatin through EWSR1::FLI1-dependent rewiring of transcription, DNA repair, and translation machinery, which could maximize the therapeutic window of the combinatory therapy. See related article by Jess et al., p. 3533.