%0 Journal Article
%T Causal relationship between iron deficiency anemia and asthma: a Mendelian randomization study.
%A Li M
%A Chen Z
%A Yang X
%A Li W
%J Front Pediatr
%V 12
%N 0
%D 2024
%M 38853780
%F 3.569
%R 10.3389/fped.2024.1362156
%X <B>UNASSIGNED: </B>Observational studies have suggested an association between iron deficiency anemia (IDA) and asthma, which may affect the occurrence of asthma. However, whether IDA is a new management goal for asthma remains to be determined.<BR><B>UNASSIGNED: </B>We conducted a two-sample Mendelian randomization(MR)analysis to assess the association between IDA and asthma.<BR><B>UNASSIGNED: </B>We performed a two-sample MR study to assess a causal relationship between IDA (ncase = 12,434, ncontrol = 59,827) and asthma (ncase = 20,629, ncontrol = 135,449). Inverse variance weighted (IVW) was used as the primary method for the analyses. Furthermore, we used weighted medians and MR-Egger to enhance robustness. Data linking genetic variation to IDA and asthma were combined to assess the impact of IDA on asthma risk.<BR><B>UNASSIGNED: </B>There are five single nucleotide polymorphisms (SNPs) were used as genetic tool variables for exposure factors. Genetically determined IDA was significantly associated with an increased risk of asthma (OR = 1.37, 95% CI: 1.09-1.72, p = 0.007). There was little heterogeneity in the MR studies and no evidence of level pleiotropy was found.<BR><B>UNASSIGNED: </B>In our MR study, our findings emphasize that IDA may be associated with a high risk of asthma, indicating a potential role for IDA in the development of asthma. Future research needs to elucidate its potential mechanisms to pave the way for the prevention and treatment of asthma.