%0 Journal Article
%T A novel function of the M2 muscarinic receptor.
%A Wess J
%A Liu L
%J Trends Pharmacol Sci
%V 45
%N 8
%D 2024 Aug 8
%M 38853101
%F 17.638
%R 10.1016/j.tips.2024.05.010
%X The M2 muscarinic receptor (M2R) is a prototypic class A G protein-coupled receptor (GPCR). Interestingly, Fasciani et al. recently identified an internal translation start site within the M2 receptor mRNA, directing the expression of a C-terminal receptor fragment. Elevated during cellular stress, this polypeptide localizes to mitochondria where it inhibits oxidative phosphorylation.