%0 Journal Article
%T COVID-19 among lung cancer patients: Data from a real-life prospective French multicentric study.
%A Olivier M
%A Julian P
%A Acya BT
%A Sophie S
%A Benoît G
%A Laurent P
%A Hugues F
%A Charles D
%A Julie O
%A Cécile D
%A Patrick D
%A Sylvie J
%A Nicolas M
%A Alexia L
%A Hugues M
%A Didier D
%A
%J Respir Med Res
%V 86
%N 0
%D 2024 Mar 4
%M 38848641
%F 3.149
%R 10.1016/j.resmer.2024.101093
%X BACKGROUND: COVID-19 started to spread early in 2020, the precise year that lung cancer (LC) patients were recruited into the prospective epidemiological cohort KBP-2020-CPHG in French hospitals. This provides a unique opportunity to study COVID-19 incidence, survival risk factors, and overall prognosis.
METHODS: COVID data was collected before vaccination was made available. Clinical characteristics were compared (COVID vs non-COVID), incidence rate ratios were calculated based on clinical characteristics, survival (1 and 3 months) was estimated and the impact of COVID-19 on the overall prognosis of the cohort was studied.
RESULTS: In 2020, 285 out of 8,999 lung cancer patients were diagnosed with COVID-19. Diagnosis was mainly based on PCR tests (86.3 %). The annual incidence was 8.3 % (95 % CI [7.4, 9.3]); it was higher in former smokers and patients with squamous cell carcinoma or small cell carcinoma than in those with adenocarcinoma, in those with a PS score ≥2 versus 0-1, and with stages III-IV versus stages I-II. The incidence was reduced in patients who received chemotherapy or immunotherapy. 64.9 % of patients were hospitalized due to COVID-19. Risk factors for death at 1 and 3 months in COVID-19 patients were age, LC stage, and PS score. Multivariate analysis showed a major prognostic impact of COVID-19 on mortality of LC patients (hazard ratio: 4.12, 95 % CI [3.42, 4.97], p < 0.001).
CONCLUSIONS: This prospective study demonstrated the high incidence of COVID-19 in LC patients and identified as risk factors for COVID-19: smoking status, histology, PS, and stage. The impact of COVID-19 on lung cancer mortality appears major.