%0 Journal Article %T The bioenergetics of nucleocytoplasmic transport. %A Luxton GWG %J J Cell Biol %V 223 %N 7 %D 2024 Jul 1 %M 38847483 %F 8.077 %R 10.1083/jcb.202405121 %X How nucleocytoplasmic transport (NCT) rates change due to cellular physiology-mediated fluctuations in GTP availability remains unclear. In this issue, Scott et al. (https://doi.org/10.1083/jcb.202308152) demonstrate that cell migration, spreading, and nucleocytoskeletal coupling impact GTP levels, thereby regulating NCT, RNA export, and protein synthesis.