%0 Journal Article
%T Abietane diterpenoids from Isodon amethystoides and their biological activities.
%A Zhou L
%A Zhao CL
%A Xu CY
%A Dong MH
%A Ye JH
%A Zhang JJ
%A Pan LT
%A Zou J
%A Zhang HJ
%J Phytochemistry
%V 225
%N 0
%D 2024 Jun 4
%M 38844058
%F 4.004
%R 10.1016/j.phytochem.2024.114171
%X Seven undescribed abietane diterpenoids [abietamethinols A-G (1-7)] were isolated from the twigs and leaves of Isodon amethystoides. Their structures were elucidated on the basis of spectroscopic methods including 2D NMR, and they were further confirmed by X-ray crystallographic data. Lophanic acid was considered as the precursor of 1-7 in the biosynthesis pathway hypothesis. These compounds were evaluated for their cytotoxic, anti-bacterial and anti-AIV (avian influenza virus) activities. Compound 5 showed 42.9% inhibitory activity against the cancer cell line SMMC-7721 at the concentration of 40 μM, 3 and 4 could inhibit the bacterial growth of Streptococcus sobrinus by 55.3% and 63.2% at the concentrations of 148.6 and 141.9 μM, respectively, and 4 was demonstrated with antiviral activity against AIV with the inhibitory effect of 68.4% at 25 μM.