%0 Journal Article
%T Predictive value of sarcopenia components for all-cause mortality: findings from population-based cohorts.
%A Westbury LD
%A Harvey NC
%A Beaudart C
%A Bruyère O
%A Cauley JA
%A Cawthon P
%A Cruz-Jentoft AJ
%A Curtis EM
%A Ensrud K
%A Fielding RA
%A Johansson H
%A Kanis JA
%A Karlsson MK
%A Lane NE
%A Lengelé L
%A Lorentzon M
%A McCloskey E
%A Mellström D
%A Newman AB
%A Ohlsson C
%A Orwoll E
%A Reginster JY
%A Ribom E
%A Rosengren BE
%A Schousboe JT
%A Dennison EM
%A Cooper C
%A  
%J Aging Clin Exp Res
%V 36
%N 1
%D 2024 Jun 6
%M 38842791
%F 4.481
%R 10.1007/s40520-024-02783-x
%X <B>BACKGROUND: </B>Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited.<BR><B>OBJECTIVE: </B>We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors.<BR><B>METHODS: </B>Participants from the Health, Aging and Body Composition Study, Osteoporotic Fractures in Men Study, and the Hertfordshire Cohort Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over 2.4-6 m. Verified deaths were recorded. Associations between sarcopenia components and mortality were examined using Cox regression with cohort as a random effect; discriminative capacity was assessed using Harrell's Concordance Index (C-index).<BR><B>RESULTS: </B>Mean (SD) age of participants (n = 8362) was 73.8(5.1) years; 5231(62.6%) died during a median follow-up time of 13.3 years. Grip strength (hazard ratio (95% CI) per SD decrease: 1.14 (1.10,1.19)) and gait speed (1.21 (1.17,1.26)), but not ALM index (1.01 (0.95,1.06)), were associated with mortality in mutually-adjusted models after accounting for age, sex, BMI, smoking status, alcohol consumption, physical activity, ethnicity, education, history of fractures and falls, femoral neck bone mineral density (BMD), self-rated health, cognitive function and number of comorbidities. However, a model containing only age and sex as exposures gave a C-index (95% CI) of 0.65(0.64,0.66), which only increased to 0.67(0.67,0.68) after inclusion of grip strength and gait speed.<BR><B>CONCLUSIONS: </B>Grip strength and gait speed may generate only modest adjunctive risk information for mortality compared with other more readily obtainable risk factors.