%0 Case Reports
%T Drug-induced liver injury secondary to tamoxifen.
%A Subhaharan D
%A Murphy G
%A Commins N
%A Azer M
%J BMJ Case Rep
%V 17
%N 6
%D 2024 Jun 5
%M 38839414
暂无%R 10.1136/bcr-2024-260098
%X Tamoxifen is a non-steroidal selective oestrogen receptor modulator commonly used in the treatment of breast cancer. It is associated with the development of fatty liver and steatohepatitis however drug-induced liver injury is rare. We report a woman in her 50s who developed malaise with an acute moderate aminotransferase elevation without jaundice 6 months after starting tamoxifen. She was not commenced on any other recent drugs and extensive investigation including infective and autoimmune liver screen, cross-sectional imaging and FibroScan were unremarkable. Liver biopsy revealed moderate lobular hepatitis with hepatocyte drop-out. Tamoxifen was ceased and the liver enzymes showed resolution over the following 3 months and improvement of her symptoms.