%0 Journal Article
%T Structural and functional neural patterns among sub-threshold bulimia nervosa: Abnormalities in dorsolateral prefrontal cortex and orbitofrontal cortex.
%A Luo L
%A Luo Y
%A Chen X
%A Xiao M
%A Bian Z
%A Leng X
%A Li W
%A Wang J
%A Yang Y
%A Liu Y
%A Chen H
%J Psychiatry Res Neuroimaging
%V 342
%N 0
%D 2024 Aug 6
%M 38833945
%F 2.493
%R 10.1016/j.pscychresns.2024.111825
%X <B>BACKGROUND: </B>Disordered eating behaviors are prevalent among youngsters and highly associated with dysfunction in neurocognitive systems. We aimed to identify the potential changes in individuals with bulimia symptoms (sub-BN) to generate insights to understand developmental pathophysiology of bulimia nervosa.<BR><B>METHODS: </B>We investigated group differences in terms of degree centrality (DC) and gray matter volume (GMV) among 145 undergraduates with bulimia symptoms and 140 matched control undergraduates, with the secondary analysis of the whole brain connectivity in these regions of interest showing differences in static functional connectivity (FC).<BR><B>RESULTS: </B>The sub-BN group exhibited abnormalities of the right dorsolateral prefrontal cortex and right orbitofrontal cortex in both GMV and DC, and displayed decreased FC between these regions and the precuneus. We also observed that sub-BN presented with reduced FC between the calcarine and superior temporal gyrus, middle temporal gyrus and inferior parietal gyrus. Additionally, brain-behavioral associations suggest a distinct relationship between these FCs and psychopathological symptoms in sub-BN group.<BR><B>CONCLUSIONS: </B>Our study demonstrated that individuals with bulimia symptoms present with aberrant neural patterns that mainly involved in cognitive control and reward processing, as well as attentional and self-referential processing, which could provide important insights into the pathology of BN.