%0 Journal Article
%T Three-dimensional modeling of aortic leaflet coaptation and load-bearing surfaces: in silico design of aortic valve neocuspidizations.
%A Macé LG
%A Fringand T
%A Cheylan I
%A Sabatier L
%A Meille L
%A Lenoir M
%A Favier J
%J Interdiscip Cardiovasc Thorac Surg
%V 0
%N 0
%D 2024 Jun 3
%M 38830038
暂无%R 10.1093/icvts/ivae108
%X <B>OBJECTIVE: </B>Three-dimensional (3D) modelling of aortic leaflets remains difficult due to insufficient resolution of medical imaging. We aimed to model the coaptation and load-bearing surfaces of the aortic leaflets and adapt this workflow to aid in the design of aortic valve neocuspidizations.<BR><B>METHODS: </B>Geometric morphometrics, using landmarks and semilandmarks, was applied to the geometric determinants of the aortic leaflets from computed tomography, followed by an isogeometric analysis using Non-Uniform Rational Basis Splines (NURBS). Ten aortic valve models were generated, measuring determinants of leaflet geometry defined as 3D NURBS curves, and leaflet coaptation and load-bearing surfaces were defined as 3D NURBS surfaces. Neocuspidizations were obtained by either shifting the upper central coaptation landmark towards the sinotubular junction or using parametric neo-landmarks placed on a centerline drawn between the centroid of the aortic root base and centroid of a circle circumscribing the three upper commissural landmarks.<BR><B>RESULTS: </B>The ratio of the leaflet free margin length to the geometric height was 1.83, whereas the ratio of the commissural coaptation height to the central coaptation height was 1.93. The median coaptation surface was 137 mm2 (IQR 58) and the median load-bearing surface was 203 mm2 (60) per leaflet. Neocuspidization multiplied the central coaptation height by 3.7 and the coaptation surfaces by 1.97 and 1.92 using the native coaptation axis and centroid coaptation axis, respectively.<BR><B>CONCLUSIONS: </B>Geometric Morphometrics reliably defined the coaptation and load-bearing surfaces of aortic leaflets, enabling an experimental 3D design for the in silico neocuspidization of aortic valves.