%0 Journal Article
%T [Pseudocarcinomatous hyperplasia of the fallopian tube: a clinicopathological analysis of sixteen cases].
%A Sun YH
%A Chen XC
%A Xiao YP
%A Tao X
%A Gu WY
%J Zhonghua Bing Li Xue Za Zhi
%V 53
%N 6
%D 2024 Jun 8
%M 38825897
暂无%R 10.3760/cma.j.cn112151-20240204-00084
%X Objective: To investigate the clinicopathological features, diagnosis and differential diagnosis of pseudocarcinomatous hyperplasia of the fallopian tubes. Methods: Sixteen cases of pseudocarcinomatous hyperplasia of the fallopian tubes diagnosed at Obstetrics and Gynecology Hospital of Fudan University from January 2011 to January 2024 were collected.The pathological sections were reviewed, the clinical and pathological data were consulted, and immunohistochemical examination was conducted along with follow-up. Results: The patients were aged from 19 to 57 years, with an average age of 41 and a median age of 38. Among the 16 cases, 4 were located in the right fallopian tubes, 6 in the left fallopian tubes, while the remaining cases presented bilaterally. The general manifestations were tubal edema, crispness and purulent secretion in the lumen. Morphologically, the fallopian tube mucosa exhibited a significant infiltration of neutrophils, lymphocytes and plasma cells. The epithelial cells of the fallopian tube displayed evident proliferation, stratification and disorganized arrangement leading to formation of small glandular cavity with back-to-back, fissure-like and sieve-like structures. Immunohistochemical analysis revealed positivity for CK7 and WT1, along with wild-type p53 expression, Ki-67 index ranged from 5% to 20%. During the follow-up period ranging from 1 to 156 months, all the patients remained free of disease. Conclusions: Pseudocarcinomatous hyperplasia of the fallopian tube is a rare non-neoplastic lesion, which can lead to epithelial hyperplasia and atypical hyperplasia. The most important significance of recognizing this lesion lies in avoiding misdiagnosis of fallopian tube cancer during intraoperative and postoperative pathological examination. This ensures that clinicians can administer correct clinical interventions.<BR>目的： 探讨输卵管假癌性增生的临床病理特征、诊断及鉴别诊断。 方法： 收集复旦大学附属妇产科医院2011年1月至2024年1月诊断的输卵管假癌性增生16例，复阅病理切片，查阅临床病理资料，并行免疫组织化学检查及随访。 结果： 16例患者年龄19~57岁，平均年龄41岁，中位年龄38岁。发生于右侧输卵管、左侧输卵管和双侧输卵管分别为4例、6例和6例。大体检查，输卵管水肿、质脆，管腔内见脓性分泌物。镜下观察，输卵管黏膜大量中性粒细胞、淋巴细胞及浆细胞浸润，输卵管上皮细胞明显增生、复层，排列紊乱，形成小腺腔、背靠背、裂隙样、筛孔状结构。免疫组织化学显示细胞角蛋白7、WT1阳性，p53均呈野生型表达，Ki-67阳性指数5%~20%。随访时间1~156个月，所有患者均无病生存。 结论： 输卵管假癌性增生是一种罕见的非肿瘤性病变，可以出现上皮增生和不典型，认识该类病变的最重要意义在于避免术中、术后病理检查中误判为输卵管癌，进而作出正确的临床处置。.