%0 Journal Article
%T Viscosity-Induced Emission of 5-(Diarylmethylene)imidazolone with Extended Conjugation via Attachment of N-Methylpyrrole at the 2-Position.
%A Ikejiri M
%A Yoshimizu A
%A Shiota F
%A Nagayama A
%A Fujisaka A
%A Kuboki Y
%A Miyashita K
%J Chem Pharm Bull (Tokyo)
%V 72
%N 5
%D 2024
%M 38825446
%F 1.903
%R 10.1248/cpb.c24-00143
%X We have developed a series of 2-monoaryl-5-diarylmethylene analogs of the green fluorescent protein chromophore to study their viscosity-induced emission (VIE) properties. The analogs were synthesized by a condensation with methyl imidate and N-(diarylmethylene)glycinate. Among the analogs, the N-methylpyrrol-2-yl-substituted analog 1h induced the most remarkable VIE behavior in triglyceride and lipid bilayers probably due to the high π-electron-rich property of the pyrrole ring. The pyrrole substituent in imidazolone analogs can be expected to become a common template for introducing VIE behavior.