%0 Journal Article
%T Diaporchalasin A, a new PDE4 inhibitory cytochalasin from Conus marmoreus-derived fungus Diaporthe sp. XMA007.
%A Liu S
%A Qin M
%A Shi Y
%A Bao J
%A Yi B
%A Fu Y
%J Nat Prod Res
%V 0
%N 0
%D 2024 Jun 2
%M 38824431
%F 2.488
%R 10.1080/14786419.2024.2355592
%X A novel cytochalasin named diaporchalasin A (1) bearing a cinnamenyl and an epoxy-macrocycloketone, and a new benzenepropionic acid derivative (2), and two known compounds (3 and 4) were isolated from Conus marmoreus-derived fungus Diaporthe sp. XMA007. Their structures were elucidated through detailed spectroscopic analysis, and the absolute configuration of 1 was determined by conformational analysis and TDDFT-ECD calculation. Their activity evaluation on PDE4 inhibition and breast cancer cell cytotoxicity were conducted, and compound 1 showed moderate inhibition on PDE4.