%0 Journal Article
%T Inborn Errors of Immunity.
%A Baloh CH
%A Chong H
%J Med Clin North Am
%V 108
%N 4
%D 2024 Jul
%M 38816112
%F 6.912
%R 10.1016/j.mcna.2023.08.006
%X Inborn errors of immunity occur in 1 in 1000 to 1 in 5000 individuals and are characterized by immune deficiency and immune dysregulation. The primary care provider (PCP) should be familiar with key features of these diagnoses including recurrent and/or severe infections, hyperinflammation, malignancy, and autoimmunity and have a low threshold to refer for evaluation. The PCP can begin a laboratory evaluation before referral by sending a complete blood count (CBC) with differential, antibody levels, vaccine titers, and possibly other tests. Management approaches vary from antibiotic prophylaxis to hematopoietic stem cell transplantation depending on the specific diagnosis.