%0 Journal Article
%T Cerebellum/liver index on baseline 18F-FDG PET/CT to improve prognostication in post-transplant lymphoproliferative disorders: a multicenter retrospective study.
%A Morland D
%A Kanagaratnam L
%A Hubelé F
%A Toussaint E
%A Choquet S
%A Kas A
%A Caquot PA
%A Haioun C
%A Itti E
%A Leprêtre S
%A Decazes P
%A Bijou F
%A Schwartz P
%A Jacquet C
%A Chauchet A
%A Matuszak J
%A Kamar N
%A Payoux P
%A  
%A Durot E
%J EJNMMI Res
%V 14
%N 1
%D 2024 May 27
%M 38801646
%F 3.434
%R 10.1186/s13550-024-01111-8
%X <B>BACKGROUND: </B>Besides International Prognostic Index (IPI) score, baseline prognostic factors of post-transplant lymphoproliferative disorders (PTLD) are poorly identified due to the rarity of the disease. New indexes derived from healthy organ uptake in baseline 18F-FDG PET/CT have been studied in immunocompetent lymphoma patients. The aim of this study is to evaluate the performances of the cerebellum-to-liver uptake ratio (denoted as CLIP) as a prognostic factor for PFS and OS. This retrospective multicenter study is based on patients with PTLD included in the K-VIROGREF cohort. The previously published threshold of 3.24 was used for CLIP in these analyses.<BR><B>RESULTS: </B>A total of 97 patients was included with a majority of monomorphic diffuse large B-cell lymphoma subtype (78.3%). Both IPI score (≥ 3) and CLIP (< 3.24) were significant risk factors of PFS with corresponding hazard ratios of 2.0 (1.0-4.0) and 2.4 (1.3-4.5) respectively. For OS, CLIP was not significant and resulted in a hazard ratio of 2.6 (p = 0.059). Neither IPI score or Total Metabolic Tumor Volume reached significance for OS.<BR><B>CONCLUSIONS: </B>CLIP is a promising predictor of PFS and perhaps OS in PTLD. Further prospective studies are needed to confirm these results.