%0 Case Reports
%T Case report: Massive hepatocellular carcinoma with complete response to the non-surgical systematic treatment strategy.
%A Li Y
%A Lai Y
%A Luo X
%A Wu J
%A Wu K
%A Ma H
%J Front Oncol
%V 14
%N 0
%D 2024
%M 38800409
%F 5.738
%R 10.3389/fonc.2024.1291131
%X UNASSIGNED: The five-year recurrence rate of hepatocellular carcinoma (HCC) remains as high as 70%. A complete clinical response has not been observed without surgical resection. Here, we report a rare case of clinical complete response and long-term survival in a patient with massive HCC receiving treatment with immunotherapy, anti-angiogenic therapy, and radiotherapy.
UNASSIGNED: A 38-year-old woman presented to our hospital for abdominal pain that persisted for 3 months. She was diagnosed as Barcelona Clinic Liver Cancer(BCLC) stage A, with a Cancer of the Liver Italian Program (CLIP) score of 3, American Joint Committee on Cancer (AJCC) Tumor-Node-Metastasis (TNM) staging systems stage IB. She refused surgical resection and trans-arterial chemoembolization and accepted a non-invasive systematic treatment strategy involving immunotherapy, anti-angiogenic therapy, and radiotherapy. Her tumor burden decreased, and she experienced partial response before radiotherapy. Following radiotherapy, she experienced a complete clinical response and has been alive for more than 36 months after her initial presentation. She is currently alive.
UNASSIGNED: A non-invasive systematic treatment strategy is a potential radical treatment option for patients with massive HCC.