%0 Journal Article
%T Dental pulp stem cells ameliorate D-galactose-induced cardiac ageing in rats.
%A El-Akabawy G
%A El-Kersh SOF
%A El-Kersh AOFO
%A Amin SN
%A Rashed LA
%A Abdel Latif N
%A Elshamey A
%A Abdallah MAAEM
%A Saleh IG
%A Hein ZM
%A El-Serafi I
%A Eid N
%J PeerJ
%V 12
%N 0
%D 2024
%M 38799055
%F 3.061
%R 10.7717/peerj.17299
%X <B>UNASSIGNED: </B>Ageing is a key risk factor for cardiovascular disease and is linked to several alterations in cardiac structure and function, including left ventricular hypertrophy and increased cardiomyocyte volume, as well as a decline in the number of cardiomyocytes and ventricular dysfunction, emphasizing the pathological impacts of cardiomyocyte ageing. Dental pulp stem cells (DPSCs) are promising as a cellular therapeutic source due to their minimally invasive surgical approach and remarkable proliferative ability.<BR><B>UNASSIGNED: </B>This study is the first to investigate the outcomes of the systemic transplantation of DPSCs in a D-galactose (D-gal)-induced rat model of cardiac ageing. Methods. Thirty 9-week-old Sprague-Dawley male rats were randomly assigned into three groups: control, ageing (D-gal), and transplanted groups (D-gal + DPSCs). D-gal (300 mg/kg/day) was administered intraperitoneally daily for 8 weeks. The rats in the transplantation group were intravenously injected with DPSCs at a dose of 1 × 106 once every 2 weeks.<BR><B>UNASSIGNED: </B>The transplanted cells migrated to the heart, differentiated into cardiomyocytes, improved cardiac function, upregulated Sirt1 expression, exerted antioxidative effects, modulated connexin-43 expression, attenuated cardiac histopathological alterations, and had anti-senescent and anti-apoptotic effects.<BR><B>UNASSIGNED: </B>Our results reveal the beneficial effects of DPSC transplantation in a cardiac ageing rat model, suggesting their potential as a viable cell therapy for ageing hearts.