%0 Journal Article
%T Heritability of cerebellar subregion volumes in adolescent and young adult twins.
%A Strike LT
%A Kerestes R
%A McMahon KL
%A de Zubicaray GI
%A Harding IH
%A Medland SE
%J Hum Brain Mapp
%V 45
%N 8
%D 2024 Jun 1
%M 38798116
%F 5.399
%R 10.1002/hbm.26717
%X Twin studies have found gross cerebellar volume to be highly heritable. However, whether fine-grained regional volumes within the cerebellum are similarly heritable is still being determined. Anatomical MRI scans from two independent datasets (QTIM: Queensland Twin IMaging, N = 798, mean age 22.1 years; QTAB: Queensland Twin Adolescent Brain, N = 396, mean age 11.3 years) were combined with an optimised and automated cerebellum parcellation algorithm to segment and measure 28 cerebellar regions. We show that the heritability of regional volumetric measures varies widely across the cerebellum (   h 2  $$ {h}^2 $$  47%-91%). Additionally, the good to excellent test-retest reliability for a subsample of QTIM participants suggests that non-genetic variance in cerebellar volumes is due primarily to unique environmental influences rather than measurement error. We also show a consistent pattern of strong associations between the volumes of homologous left and right hemisphere regions. Associations were predominantly driven by genetic effects shared between lobules, with only sparse contributions from environmental effects. These findings are consistent with similar studies of the cerebrum and provide a first approximation of the upper bound of heritability detectable by genome-wide association studies.