%0 Journal Article
%T Increased CSF DOPA Decarboxylase Correlates with Lower DaT-SPECT Binding: Analyses in Biopark and PPMI Cohorts.
%A Khosousi S
%A Sturchio A
%A Appleton E
%A Paslawski W
%A Ta M
%A Nalls M
%A Singleton AB
%A Iwaki H
%A Svenningsson P
%J Mov Disord
%V 0
%N 0
%D 2024 May 26
%M 38798037
%F 9.698
%R 10.1002/mds.29835
%X <B>BACKGROUND: </B>Recent studies identified increased cerebrospinal fluid (CSF) DOPA decarboxylase (DDC) as a promising biomarker for parkinsonian disorders, suggesting a compensation to dying dopaminergic neurons. A correlation with 123I-FP-CIT-SPECT (DaT-SPECT) imaging could shed light on this link.<BR><B>OBJECTIVE: </B>The objective is to assess the relationship between CSF DDC levels and DaT-SPECT binding values.<BR><B>METHODS: </B>A total of 51 and 72 Parkinson's disease (PD) subjects with available DaT-SPECT and CSF DDC levels were selected from the PPMI and Biopark cohorts, respectively. DDC levels were analyzed using proximity extension assay and correlated with DaT-SPECT striatal binding ratios (SBR). All analyses were corrected for age and sex.<BR><B>RESULTS: </B>CSF DDC levels in PD patients correlated negatively with DaT-SPECT SBR in both putamen and caudate nucleus. Additionally, SBR decreased with increased DDC levels over time in PD patients.<BR><B>CONCLUSIONS: </B>CSF DDC levels negatively correlate with DaT-SPECT SBR in levodopa-treated PD. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.