%0 Journal Article
%T Molecular Diagnosis of Nasopharyngeal Carcinoma: Past and Future.
%A Hsu CL
%A Chang YS
%A Li HP
%J Biomed J
%V 0
%N 0
%D 2024 May 23
%M 38796105
%F 7.892
%R 10.1016/j.bj.2024.100748
%X Nasopharyngeal carcinoma (NPC) is a malignant tumor originated from the nasopharynx epithelial cells and has been linked with Epstein-Barr virus (EBV) infection, dietary habits, environmental and genetic factors. It is a common malignancy in Southeast Asia, especially with gender preference among men. Due to its non-specific symptoms, NPC is often diagnosed at a late stage. Thus, the molecular diagnosis of NPC plays a crucial role in early detection, treatment selection, disease monitoring, and prognosis prediction. This review aims to provide a summary of the current state and the latest emerging molecular diagnostic techniques for NPC, including EBV-related biomarkers, gene mutations, liquid biopsy, and DNA methylation. Challenges and potential future directions of NPC molecular diagnosis will be discussed.