%0 Journal Article %T A Revolution in the Treatment of Obesity. %A Spector R %J Am J Med %V 0 %N 0 %D 2024 May 22 %M 38788825 %F 5.928 %R 10.1016/j.amjmed.2024.05.023 %X Forty percent of Americans are obese and 20% are overweight. Until recently, notwithstanding great efforts to combat this chronic, worsening epidemic, the only therapy that "worked" was surgery. However, recently, a new class of safe drugs (incretins) have been developed that cause obese patients to lose ∼20 to 25% of their body weight. Herein we recount this revolution and its implications.