%0 Journal Article
%T Current management of familial adenomatous polyposis.
%A Lauricella S
%A Rausa E
%A Pellegrini I
%A Ricci MT
%A Signoroni S
%A Palassini E
%A Cavalcoli F
%A Pasanisi P
%A Colombo C
%A Vitellaro M
%J Expert Rev Anticancer Ther
%V 24
%N 6
%D 2024 Jun 24
%M 38785081
%F 3.627
%R 10.1080/14737140.2024.2344649
%X <B>UNASSIGNED: </B>APC-associated polyposis is a rare hereditary disorder characterized by the development of multiple adenomas in the digestive tract. Individuals with APC-associated polyposis need to be managed by specialized multidisciplinary teams in dedicated centers.<BR><B>UNASSIGNED: </B>The study aimed to review the literature on Familial adenomatous polyposis (FAP) to provide an update on diagnostic and surgical management while focusing on strategies to minimize the risk of desmoid-type fibromatosis, cancer in anorectal remnant, and postoperative complications. FAP individuals require a comprehensive approach that includes diagnosis, surveillance, preventive surgery, and addressing specific extracolonic concerns such as duodenal and desmoid tumors. Management should be personalized considering all factors: genotype, phenotype, and personal needs. Total colectomy and ileo-rectal anastomosis have been shown to yield superior QoL results when compared to Restorative Procto colectomy and ileopouch-anal anastomosis with acceptable oncological risk of developing cancer in the rectal stump if patients rigorously adhere to lifelong endoscopic surveillance. Additionally, a low-inflammatory diet may prevent adenomas and cancer by modulating systemic and tissue inflammatory indices.<BR><B>UNASSIGNED: </B>FAP management requires a multidisciplinary and personalized approach. Integrating genetic advances, innovative surveillance techniques, and emerging therapeutic modalities will contribute to improving outcomes and quality of life for FAP individuals.