%0 Journal Article
%T Comprehensive assessment of ocular parameters for identifying diagnostic indicators of diabetic peripheral neuropathy.
%A Chen Y
%A Xu Z
%A Liang A
%A Chen R
%A Wang Z
%A Chen X
%A Zheng K
%A Lu P
%A Liang H
%A Cao D
%A Zhang L
%J Acta Diabetol
%V 0
%N 0
%D 2024 May 23
%M 38780614
%F 4.087
%R 10.1007/s00592-024-02299-w
%X <B>OBJECTIVE: </B>To explore variations in systemic and ocular parameters among patients with diabetes, both with and without diabetic peripheral neuropathy (DPN) and to identify sensitive indicators for DPN diagnosis.<BR><B>METHODS: </B>Ninty-five patients with type 2 diabetes mellitus (T2DM) were involved in this cross-sectional study, including 49 without DPN and 46 with DPN. Ocular parameters were obtained using optical coherence tomography angiography (OCTA) and corneal confocal microscopy (CCM).<BR><B>RESULTS: </B>Patients with DPN presented with significantly higher HbA1c (p < 0.05) and glycated albumin (GA, p < 0.01) levels, increased prevalence of diabetic retinopathy (DR, p < 0.05), and lower serum albumin (ALB, p < 0.01) and red blood cell (RBC, p < 0.05) levels. Ocular assessments revealed reduced corneal nerve fiber length (CNFL, p < 0.001) and enlarged foveal avascular zone (FAZ) area (p < 0.05) in DPN group. Logistic regression analysis indicated a significant association of presence of DR, RBC, GA, ALB, CNFL and DPN (p < 0.05, respectively). In the binary logistic regression for DPN risk, all three models including the presence of DR and CNFL exhibited the area under the curve (AUC) exceeding 0.8.<BR><B>CONCLUSIONS: </B>The study establishes a strong correlation between ocular parameters and DPN, highlighting CCM's role in early diagnosis. Combining systemic and ocular indicators improves DPN risk assessment and early management.