%0 Journal Article
%T Decoding the Enigma: Translation Termination in Human Mitochondria.
%A Krüger A
%A Kovalchuk D
%A Shiriaev D
%A Rorbach J
%J Hum Mol Genet
%V 33
%N 0
%D 2024 May 22
%M 38779770
%F 5.121
%R 10.1093/hmg/ddae032
%X Mitochondrial translation is a complex process responsible for the synthesis of essential proteins involved in oxidative phosphorylation, a fundamental pathway for cellular energy production. Central to this process is the termination phase, where dedicated factors play a pivotal role in ensuring accurate and timely protein production. This review provides a comprehensive overview of the current understanding of translation termination in human mitochondria, emphasizing structural features and molecular functions of two mitochondrial termination factors mtRF1 and mtRF1a.