%0 Journal Article
%T Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms.
%A Citarella BW
%A Kartsonaki C
%A Ibáñez-Prada ED
%A Gonçalves BP
%A Baruch J
%A Escher M
%A Pritchard MG
%A Wei J
%A Philippy F
%A Dagens A
%A Hall M
%A Lee J
%A Kutsogiannis DJ
%A Wils EJ
%A Fernandes MA
%A Tirupakuzhi Vijayaraghavan BK
%A Panda PK
%A Martin-Loeches I
%A Ohshimo S
%A Fatoni AZ
%A Horby P
%A Dunning J
%A Rello J
%A Merson L
%A Rojek A
%A Vaillant M
%A Olliaro P
%A Reyes LF
%A  
%J Heliyon
%V 10
%N 10
%D 2024 May 30
%M 38779000
%F 3.776
%R 10.1016/j.heliyon.2024.e29591
%X <B>UNASSIGNED: </B>COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission.<BR><B>UNASSIGNED: </B>This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not.<BR><B>UNASSIGNED: </B>Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83-0.93]).<BR><B>UNASSIGNED: </B>Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders.