%0 Journal Article
%T Tenascin-C in patients with central nervous system infections.
%A Zachariassen M
%A Thomsen MM
%A Hillig T
%A Trier-Petersen P
%A Jensen AV
%A Friis-Hansen LJ
%A Brandt CT
%J J Neuroimmunol
%V 392
%N 0
%D 2024 Jul 15
%M 38776710
%F 3.221
%R 10.1016/j.jneuroim.2024.578373
%X <B>BACKGROUND: </B>The extracellular matrix protein tenascin-C has been discovered to be an important regulator of the response to tissue injury and repair in cerebrovascular diseases. This study investigated if tenascin-C is released in response to infections in the central nervous system (CNS).<BR><B>METHODS: </B>Tenascin-C concentration in the cerebrospinal fluid (CSF) was measured in patients, (>18 years) with and without CNS infections, admitted to a department of infectious diseases in Denmark. CSF tenascin-C was measured on the Meso-scale platform.<BR><B>RESULTS: </B>174 patients were included of which 140 were diagnosed with a CNS infection and 34 where this was ruled out (control group). Median CSF tenascin-C levels were significantly higher among patients with bacterial meningitis (147 pg/mL), viral meningitis (33 mg/mL), viral encephalitis (39 pg/mL) and Lyme neuroborreliosis (45 pg/mL) when compared to controls (21 pg/mL). Correlations between tenascin-C and CSF markers of inflammation and age were only moderate.<BR><B>CONCLUSIONS: </B>Levels of CSF tenascin-C are higher among patients with bacterial and viral neuroinfections, already on admission, but exhibit only a modest correlation with baseline indices of neuroinflammation. CSF tenascin-C is highest among patients with bacterial meningitis compared to the other CNS infections. Patients with unfavorable outcomes presented with higher median CSF tenascin-C than their counterparts.