%0 Journal Article
%T Clinical phenotype of anaerobic bacteremia unaccompanied by detectable abscess lesion: a 10-year retrospective, multicenter, observational-cohort study.
%A Nagaoka K
%A Iwanaga N
%A Murai Y
%A Kawasuji H
%A Miura M
%A Sato Y
%A Ito H
%A Terasaki Y
%A Takazono T
%A Kosai K
%A Sugano A
%A Morinaga Y
%A Yanagihara K
%A Mukae H
%A Yamamoto Y
%J Infection
%V 0
%N 0
%D 2024 May 20
%M 38767831
%F 7.455
%R 10.1007/s15010-024-02298-7
%X <B>OBJECTIVE: </B>Despite the importance of abscess lesions in clinical decisions regarding anaerobic bacteremia (AB), their impact on clinical characteristics remains unclear. Herein, we aimed to elucidate the clinical factors associated with AB that were unaccompanied by detectable abscess lesions during the initial phase of infection.<BR><B>METHODS: </B>This was a multicenter retrospective observational study involving patients with culture-proven AB at six tertiary hospitals in Japan between January 2012 and March 2022. Data on clinical characteristics, laboratory and radiological findings were collected, and their associations with the absence of detectable abscess lesions were analyzed.<BR><B>RESULTS: </B>In total, 393 participants were included. Abscess lesions were absent in 42.7% of the entire cohort and detectable in the remaining patients. No differences were identified in the malignancy, severity, or 30-day mortality between patients with and without detectable abscess lesions. Multivariate logistic regression analysis adjusted for age and the modified Charlson comorbidity score revealed that the immunosuppressive status (febrile neutropenia or corticosteroid use), C-reactive protein (CRP) level ≤9.8 mg/dL at onset, and the presence of gram-positive anaerobic rods (GPARs) were independently associated with AB unaccompanied by detectable abscess lesions [odds ratios (ORs) 3.24, 3.00, and 2.81, respectively; p < 0.05].<BR><B>CONCLUSIONS: </B>This study elucidated distinctive clinical and microbiological characteristics of AB unaccompanied by detectable abscess lesions, with relatively lower CRP elevation, immunosuppressive status, and GPARs as the causative anaerobes.