%0 Editorial %T Navigating the controversy regarding antibiotic prophylaxis in acute variceal bleeding. %A Aguirre-Villarreal D %A García-Juárez I %J World J Gastroenterol %V 30 %N 18 %D 2024 May 14 %M 38764763 %F 5.374 %R 10.3748/wjg.v30.i18.2485 %X Antibiotic prophylaxis in patients with cirrhosis and acute variceal bleeding is part of the standard of care according to most clinical guidelines. However, with recent evidence arguing against antibiotic prophylaxis, the role of this intervention has become less clear.