%0 Journal Article %T A new superhero, the intraepithelial mast cell, joins the "Guardians of the Gut". %A Zaini A %A Harris NL %J Immunity %V 57 %N 5 %D 2024 May 14 %M 38749395 %F 43.474 %R 10.1016/j.immuni.2024.04.020 %X The intestinal epithelium interacts with immune cells to support tissue homeostasis and coordinate responses against pathogens. In this issue of Immunity, Yang et al. unveil a central role for mast cell-epithelial cell interactions in orchestrating protective type 2 immune responses following intestinal helminth infection.