%0 Journal Article
%T Common neural dysfunction of economic decision-making across psychiatric conditions.
%A Feng C
%A Liu Q
%A Huang C
%A Li T
%A Wang L
%A Liu F
%A Eickhoff SB
%A Qu C
%J Neuroimage
%V 294
%N 0
%D 2024 Jul 1
%M 38735423
%F 7.4
%R 10.1016/j.neuroimage.2024.120641
%X Adaptive decision-making, which is often impaired in various psychiatric conditions, is essential for well-being. Recent evidence has indicated that decision-making capacity in multiple tasks could be accounted for by latent dimensions, enlightening the question of whether there is a common disruption of brain networks in economic decision-making across psychiatric conditions. Here, we addressed the issue by combining activation/lesion network mapping analyses with a transdiagnostic brain imaging meta-analysis. Our findings indicate that there were transdiagnostic alterations in the thalamus and ventral striatum during the decision or outcome stage of decision-making. The identified regions represent key nodes in a large-scale network, which is composed of multiple heterogeneous brain regions and plays a causal role in motivational functioning. The findings suggest that disturbances in the network associated with emotion- and reward-related processing play a key role in dysfunctions of decision-making observed in various psychiatric conditions. This study provides the first meta-analytic evidence of common neural alterations linked to deficits in economic decision-making.