%0 Journal Article
%T Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project).
%A Serradilla-Martín M
%A Villodre C
%A Falgueras-Verdaguer L
%A Zambudio-Carroll N
%A Castell-Gómez JT
%A Blas-Laina JL
%A Borrego-Estella V
%A Domingo-Del-Pozo C
%A García-Plaza G
%A González-Rodríguez FJ
%A Montalvá-Orón EM
%A Moya-Herraiz Á
%A Paterna-López S
%A Suárez-Muñoz MA
%A Alkorta-Zuloaga M
%A Blanco-Fernández G
%A Dabán-Collado E
%A Gómez-Bravo MA
%A Miota-de-Llamas JI
%A Rotellar F
%A Sánchez-Pérez B
%A Sánchez-Cabús S
%A Pacheco-Sánchez D
%A Rodríguez-Sanjuan JC
%A Varona-Bosque MA
%A Carrión-Álvarez L
%A de la Serna-Esteban S
%A Dopazo C
%A Martín-Pérez E
%A Martínez-Cecilia D
%A Castro-Santiago MJ
%A Dorcaratto D
%A Gutiérrez-Díaz ML
%A Asencio-Pascual JM
%A Burdío-Pinilla F
%A Carracedo-Iglesias R
%A Escartín-Arias A
%A Ielpo B
%A Rodríguez-Laiz G
%A Valdivieso-López A
%A De-Vicente-López E
%A Alonso-Orduña V
%A Ramia JM
%J Cancers (Basel)
%V 16
%N 9
%D 2024 Apr 26
%M 38730631
%F 6.575
%R 10.3390/cancers16091676
%X (1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11.1%) using the liver-first approach, 63 (42.0%) in hospitals performing <50 hepatectomies/year. The proportion of patients as ASA III was significantly higher in centers performing ≥50 hepatectomies/year (difference: 18.9%; p = 0.0213). In 81.1% of the cases, the primary tumor was in the rectum or sigmoid colon. In total, 40% of the patients underwent major hepatectomies. The surgical approach was open surgery in 87 (58.0%) patients. Resection margins were R0 in 78.5% of the patients. In total, 40 (26.7%) patients had complications after the liver resection and 36 (27.3%) had complications after the primary resection. One-hundred and thirty-two (89.3%) patients completed the therapeutic regime. (4) Conclusions: There were no differences in the surgical outcomes between the centers performing <50 and ≥50 hepatectomies/year. Further analysis evaluating factors associated with clinical outcomes and determining the best candidates for this approach will be subsequently conducted.