%0 Journal Article
%T Severe pertussis in infants: a scoping review.
%A Guo S
%A Zhu Y
%A Guo Q
%A Wan C
%J Ann Med
%V 56
%N 1
%D 2024 Dec
%M 38728617
%F 5.348
%R 10.1080/07853890.2024.2352606
%X <B>UNASSIGNED: </B>Pertussis (Whooping Cough) is a respiratory infection caused by Bordetella pertussis. Pertussis usually occurs in childhood; severe infections are most common in infants. It can be fatal with severe complications such as pulmonary hypertension, heart failure, and encephalitis.<BR><B>UNASSIGNED: </B>We sought to synthesize the existing literature on severe pertussis in infants and inform further study.<BR><B>UNASSIGNED: </B>A scoping review was performed based on the methodological framework developed by Arksey & O'Malley. Search in Pubmed and Embase databases, with no restrictions on the language and date of publication.<BR><B>UNASSIGNED: </B>Of the 1299 articles retrieved, 64 were finally included. The selected articles were published between 1979 and 2022, with 90.6% (58/64) of the studies in the last two decades. The studies covered epidemiology, pathology, clinical characteristics, risk factors, treatments, and burden of disease.<BR><B>UNASSIGNED: </B>The literature reviewed suggests that studies on severe pertussis in infants covered a variety of clinical concerns. However, these studies were observational, and experimental studies are needed to provide high-quality evidence.