%0 Systematic Review %T Psychedelics and Evidence-based Psychotherapy: A Systematic Review with Recommendations for Advancing Psychedelic Therapy Research. %A Leone L %A McSpadden B %A DeMarco A %A Enten L %A Kline R %A Fonzo GA %J Psychiatr Clin North Am %V 47 %N 2 %D 2024 Jun %M 38724126 %F 2.832 %R 10.1016/j.psc.2024.02.006 %X Administration of psychedelics for mental health treatment, typically referred to as "psychedelic-assisted therapy," is a broad term with a very heterogeneous implementation. Despite increasing interest in the clinical application of psychedelic compounds for psychiatric disorders, there is no consensus on how to best integrate the psychedelic experience with evidence-based psychotherapeutic treatment. This systematic review provides a timely appraisal of existing approaches to combining psychotherapy with psychedelics and provides clear recommendations to best develop, optimize, and integrate evidence-based psychotherapy with psychedelic administration for straightforward scientific inference and maximal therapeutic benefit.