%0 Case Reports
%T Mucinous cystadenoma and benign mesonephric-like proliferation in the ovary - Further evidence for clonal relationship.
%A Hiller GGR
%A Höhn AK
%A Krücken I
%A Monecke A
%A Reske D
%A Brambs CE
%A Horn LC
%J Pathol Res Pract
%V 258
%N 0
%D 2024 Jun 6
%M 38723326
%F 3.309
%R 10.1016/j.prp.2024.155336
%X Mesonephric-like adenocarcinomas rarely occur in the uterus and the ovary. Benign mesonephric-like (ML) proliferations and hyperplasia have been described solely within the ovary. Pathogenetic data are very limited. We report a case with microscopic focus of benign ML-proliferation in association with mucinous cystadenoma in the ovary. The immunophenotype was distinct (mucinous tumor: focal weak nuclear positivity for PAX-8, CK 7, patchy cytoplasmic positivity for p16 and negativity for estrogen receptor, CD 10, TTF-1, p53 wildtype; mesonephric component: diffusely positive for PAX-8, CK 7, luminal CD 10, TTF-1, focal staining for estrogen receptor, patchy cytoplasmic for p16, p53 wildtype). On NGS-analysis there was clonal mutation of KRAS p.G12C. The data provide additional evidence for the concept of transdifferentiation (Müllerian tissue representing Wolffian/mesonephric features on histology and immunostaining) within the pathogenesis of mesonephric proliferation of the female genital tract and demonstrate the clonal relationship between these distinct morphologic components.