%0 Journal Article
%T Chemical constituents from uncaria laevigata and their vasodilatory activities in vitro and action mechanism.
%A Huang L
%A Wang ZM
%A Zhao Q
%A Li HJ
%A Wu YC
%J Nat Prod Res
%V 0
%N 0
%D 2024 May 9
%M 38721687
%F 2.488
%R 10.1080/14786419.2024.2352871
%X A new triterpenoid compound 1* (scandine A1) was obtained from 95% ethanol extract of Uncaria laevigata. Meanwhile, eleven described compounds were also isolated for the first time from Uncaria laevigata. Herein, compound 2 exhibited strong diastolic cardio-cerebrovascular activity (EC50BA = 9.22 μM and EC50CA = 14.65 μM), which was not been previously described. Compound 1* also showed certain diastolic cardio-cerebrovasculary activity. Network pharmacology indicated that the diastolic cardio-cerebrovascular activity of compound 2 was most correlated with the Ras signalling pathway. Molecular docking confirmed that it exhibited strong binding activity with target protein (matrix metalloproteinase inhibitor-1). Moreover, compound 2 demonstrated significant potential on cardio-cerebrovascular activity in vitro. Overall, compounds 1* and 2 with good diastolic cardio-cerebrovascular activity were discovered in this work.