%0 Case Reports %T Leptospirosis: a clinical and diagnostic challenge. %A Saliba J %A Vassallo C %A Saliba J %A Pace Bardon M %J BMJ Case Rep %V 17 %N 5 %D 2024 May 7 %M 38719252 暂无%R 10.1136/bcr-2023-256905 %X We present the case of a man in his early 50s who presented with a history of fever, malaise and jaundice. Initial investigations showed liver and renal dysfunction with no discernible cause for the septic process. On starting intravenous antibiotics, the patient developed a septic-shock-like reaction requiring transfer to intensive care. A diagnosis of leptospirosis was eventually established through an extensive and thorough history leading to a stepwise approach to investigations. Treatment targeting leptospirosis was delivered with noticeable clinical improvement.