%0 Journal Article
%T Efficacy of a New Hyaluronic Acid Dermal Filler on Nasolabial Folds Correction: A Prospective, Comparative, Double-Blinded Clinical Trial.
%A Lheritier C
%A Converset S
%A Rzany BJ
%A Cartier H
%A Ascher B
%J Dermatol Surg
%V 50
%N 8
%D 2024 Aug 1
%M 38713883
%F 2.914
%R 10.1097/DSS.0000000000004207
%X <B>BACKGROUND: </B>Hyaluronic acid-based dermal fillers are the cornerstones of wrinkle correction and facial contour redefinition.<BR><B>OBJECTIVE: </B>To assess the efficacy and safety of EST LF compared with RES L for the treatment of nasolabial folds (NLFs).<BR><B>METHODS: </B>In this prospective, split-face, randomized, investigator and subject-blinded trial, 45 subjects with moderate-to-severe symmetrical NLFs were randomized to EST LF on one side of the face and RES L on the other side and were followed up for 9 months. The primary end point was change in WSRS score from the baseline to Month 1 (M1). Secondary end points included changes in WSRS score at other time points, aesthetic improvement, wrinkle volume quantification, adverse events, and local tolerance.<BR><B>RESULTS: </B>The efficacy difference between EST LF and RES L at M1 was in favor of EST LF (-0.16, CI, -0.28 to -0.03]), demonstrating its noninferiority. Considering other time points, significant differences were observed at 3 and 6 months for EST LF , assessed with WSRS, GAIS, or NLF volume quantification. Both treatments were well tolerated.<BR><B>CONCLUSIONS: </B>EST LF is effective and well tolerated for the treatment of NLFs.